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Proteases producing Pseudomonas aeruginosa has often been implicated in human respiratory infections. This study was to evaluate pathogenic effects on mouse lung of 4 strains (A10-341, A10-403, NC-5, and IFO 3455) of Pseudomonas aeruginosa with known proteases production and mouse lethality in experimental model. It was found that histopathologic effects of pseudomonal proteases on mouse lung include increased hemorrhage, emphysema, infiltration of mononuclear cells, non-inflammatory edema of alveolar septa, and alveolar exudation. Rates of destruction of alveolar architecture and necrosis of alveolar septal cells were correlated with the degrees of mouse lethality of each strain and the cause of these effects seemed to be related with the endotoxic activities of Pseudomonas aeruginosa in vivo.
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